DNA TECHNOLOGY (USE & APPLICATION) REGULATION BILL
Key Provisions :
1- DNA testing is allowed in following matters
- Offences under the Indian Penal Code, 1860.
 - for civil matters such as paternity suits.
 - for matters related to establishment of individual identity.
 
2- Collection of DNA: the investigating authorities may collect bodily substances of persons.
Requirement of consent for collection in certain situations- written consent for offences with  upto 7 years imprisonment,not required in case of more than 7 years.
3- DNA Data Bank– A National DNA Databank and regional DNA Databanks will store DNA Profiles in a specified format.
4- Removal of DNA profiles: The Bill provides for removal of the DNA profiles of the following persons:
✓ of a suspect if a police report is filed or court order given,
✓ of an undertrial if a court order is given, and
✓ on written request, for persons who are not a suspect,  offender or undertrial, from the crime scene or missing persons’ index.
5 – Establishment of DNA Regulatory Board: which will supervise the DNA Data Banks and DNA laboratories.
6 – Penalties for various offences, including disclosure of DNA information or using DNA sample without authorization have been provided.
Gene Therapy
It refers to the process of introduction, removal or change in content of an individual’s genetic material with the goal of treating the disease and a possibility of achieving long term cure.
2 Types:
1- Germ-line gene therapy: The concept of germ-line gene therapy is to introduce gene modified cells into the germline, that can be transmitted vertically across generations.
Prohibited In India.
2- Somatic cell gene therapy: It affects the targeted cells/tissue/organs in the patient, and is not passed on to subsequent  generations. It is legal in India. This also
includes genome modification as done in CRISPR-related and other technologies. It has two categories:
✓ ex vivo- cells obtained from an individual are genetically modified/corrected outside the body followed by transplantation into the same or a different individual.
✓ in vivo– the gene of interest is delivered directly to target cells/ tissues/organs (like liver, pancreas, muscle, heart etc.) in the patients.
Gene delivery can be carried out by viral or non- viral vector systems.
Gene Therapy Product (GTP)
• It is defined as any biological entity, having the required gene, that could introduce modifications in the genome for therapeutic benefit.
• GTPs work by repairing, replacing or deactivating dysfunctional disease-causing genes aiming to restore normal function.
• GTPs include:
o Recombinant viral vectors: adenovirus, retrovirus
o Non-viral vectors: naked DNA transfection.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)
It is the DNA-targeting part of the system which consists of an RNA molecule, or ‘guide’, designed to bind to specific DNA bases through complementary base-pairing.
o CRISPR-associated nucleases (Cas9) is the nuclease part that cuts the DNA.
Asked in 2019 Prelims Exam
o Lulu and Nana are the world’s first gene edited human babies using CRISPR gene editing.
Retrovirus: It is family of viruses with RNA as genetic material that can integrate their genome into the DNA of host cells, they invade.
Transgene: It is a genetic material that is artificially introduced into the genome of another organism.
MANAV: HUMAN ATLAS INITIATIVE
- Launched by Dept of Biotechnology
 - MANAV Project aims to create an open and interactive atlas of human biology, compiling, curating and synthesizing data at the molecular, cellular, tissue and organismic level from scientific literature and public databases.
 - For the first time, Indian scientists will be mapping every single tissue of the human body to have deeper understanding of the roles of tissues and cells linked to various diseases.
 
UMMID
- UMMID (Unique Methods of Management and treatment of Inherited Disorders)
 - It aims to create awareness about genetic disorders amongst clinicians and establish molecular diagnostics in hospitals so that the benefits of developments in medical genetics could reach patients.
 - It is supported by Department of Biotechnology.
 
Genome India Project
- Union government has given clearance to an ambitious gene mapping project known as the Genome India Project.
 - The project has been cleared by Department of Biotechnology (under the Ministry of Science and Technology).
 - The Centre for Brain Research, an autonomous institute of IISc, Bengaluru will serve as the nodal point of the project.
 - The first stage of the project will look at samples of 10,000 persons from all over the country to form a grid that will enable the development of a Reference Genome.
 - As a precursor to this project, Council of Scientific and Industrial Research (CSIR) last year concluded a six-month exercise of conducting a “whole-genome sequence” of a 1,008 Indians under “IndiGen” programme.
 
GM Crops
Genetic Engineering Appraisal Committee (GEAC) asked Maharashtra Government to initiate action to stop cultivation of illegal Herbicide-Tolerant variety of Bt Cotton (Htbt cotton).
Only GM crop permitted for cultivation in India is Bt Cotton.
Only GM cotton permitted to be grown in India are hybrids/varieties that contain ‘cry1Ac’ and ‘cry2Ab’ genes, isolated from the soil bacterium Bacillus thuringiensis (Bt) and coding for proteins toxic to bollworm insect pests.
GEAC
- GEAC established under Ministry of Environment, Forest and Climate Change is the apex body for approval of activities involving large scale use of hazardous microorganisms and recombinants in research and industrial production from the environmental angle.
 - The GEAC is also responsible for approval of proposals relating to release of genetically engineered organisms and products into the environment including experimental field trials.
 
Golden Rice
- International Rice Research Institute – headquartered in Los Baños, Philippines – along with its partners has successfully cultivated Golden Rice in a controlled environment on IRRI campus.
 - Golden rice is the collective name of rice varieties that are genetically modified to counter vitamin A deficiency in developing countries.
 - Golden rice differs from standard rice in that it contains extra genes one from maize and one from bacterial origin together responsible for the production of provitamin A (betacarotene) in the rice grain.
 - Provitamin A colors the grains yellow orange, hence the name ‘Golden Rice’.
 - Cost of cultivation same as normal rice.
 - Reduces water use by 30 percent.
 - Should not be stored for more than 3 months.
 
Muktoshri (IET 21845)
• It is a commercialised rice variety that is resistant to arsenic.
• It was developed jointly by West Bengal’s Agriculture Department and National Botanical Research Institute, Lucknow.
Geotail
- Chandrayaan-2 had detected charged particles in Moon’s soil during the orbiter’s passage through the “geotail”.
 - CLASS (Chandrayaan 2 Large Area Soft X-ray Spectrometer), is an instrument on Chandrayaan-2, designed to detect signatures of elements in the Moon’s soil- this instrument observed the phenomena.
 
What is geotail and how is it formed?
• The Sun emits the solar wind, which is a continuous stream of charged particles (like electrons, protons, alpha particles etc). These particles are present in the upper atmosphere of the Sun, called the Corona.
• Since the Earth has a magnetic field, it obstructs this solar wind plasma.
• This interaction results in the formation of a magnetic envelope around Earth called magnetosphere. 
• On the Earth side facing the Sun, this magnetosphere is compressed into a region that is approximately three to four times the Earth radius.
• On the opposite side, the envelope is stretched into a long tail, which extends beyond the orbit of the Moon. It is this that is called the geotail.
NAVIC
- Global standards body 3GPP, which develops protocols for mobile telephony, has approved India’s regional navigation system NaVIC.
 - It will boost commercial use of NAVIC by device makers.
 - It will also bring NaVIC technology to the commercial market for its use in 4G, 5G and Internet of Things (IOT).
 - Integrated circuits and products based on NAVIC can be developed now.
 - 3GPP currently has global navigation satellite system support from BDS (Chinese), Galileo (European), GLONASS (Russia) and GPS (USA) for cellular positioning systems.
 - US congress has agreed to designate India’s NavIC as its allied navigational satellite system along with Galileo of European Union and QZSS of Japan.
 - US designated Russia’s GLONASS and Chinese Beidou as a “non-allied system”.
 
IRNSS (NAVIC)
IRNSS is an independent regional navigation satellite system being developed by India. It is designed to provide accurate position information service to users in India as well as the region extending up to 1500 km from its boundary, which is its primary service area. An Extended Service Area lies between primary service area and area enclosed by the rectangle from Latitude 30 deg South to 50 deg North, Longitude 30 deg East to 130 deg East.
IRNSS will provide two types of services, namely, Standard Positioning Service (SPS) which is provided to all the users and Restricted Service (RS), which is an encrypted service provided only to the authorised users. The IRNSS System is expected to provide a position accuracy of better than 20 m in the primary service area.
Some applications of IRNSS are:
- Terrestrial, Aerial and Marine Navigation
 - Disaster Management
 - Vehicle tracking and fleet management
 - Integration with mobile phones
 - Precise Timing
 - Mapping and Geodetic data capture
 - Terrestrial navigation aid for hikers and travellers
 - Visual and voice navigation for drivers
 
Many questions from IRNSS topic asked in Prelims Exam earlier.
The space segment consists of the IRNSS constellation of eight satellites, NavIC.
3 satellites are located in suitable orbital slots in the geostationary orbit and the remaining 4 are located in geosynchronous orbits with the required inclination and equatorial crossings in two different planes. All the satellites of the constellation are configured identically. The satellites are configured with I-1K Bus to be compatible for launch on-board PSLV.
GEMINI
Government of India has launched the Gagan Enabled Mariner’s Instrument for Navigation and Information (GEMINI) device, a satellite-based advisory service for deep-sea fishermen.
- It has been developed to disseminate seamless and effective emergency information and communication on disaster warnings, Potential Fishing Zones (PFZ) and Ocean States Forecasts (OSF) to fishermen.
 - It has been developed by the Indian National Centre for Ocean Information Services (INCOIS), an autonomous body under the Ministry of Earth Sciences (MoES) and Airports Authority of India (AAI).
 - This device receives and transfers the data received from GAGAN satellites to a mobile through bluetooth communication.
 
INDIAN DATA RELAY SATELLITE SYSTEM (IDRSS)
- India plans for its own space-to-space tracking and communication of its space assets by putting up a new satellite series called Indian Data Relay Satellite System (IDRSS).
 - A set of 2 IDRSS satellites will be placed in geostationary orbit, enabling satellite to satellite communication and transfer of data.
 - It will track, send and receive real-time information from other Indian satellites, in particular those in low-earth orbits (LEO) which have limited coverage of earth.
 - It will also be useful in monitoring launches and benefitting crew members of the Gaganyaan mission ensuring mission control throughout their travel.
 - It is also significant for space docking, space station, as well as distant expeditions to moon, Mars and Venus.
 - It will also reduce the dependence on the ground stations in tracking satellites.
 - US, China, Japan and Europe – already have such DRS systems.
 
NEWSPACE INDIA
- Indian Space Research Organisation (ISRO), inaugurated its commercial arm NewSpace India Limited (NSIL), in Bengaluru.
 - It was incorporated for commercially utilising research and development activities carried out by ISRO.
 
Objectives 
- To scale up industry participation in Indian space programmes as it will act as an aggregator for all space related activities in industry and develop  private entrepreneurship in space related
technologies. - Manufacturing and production of Small Satellite Launch Vehicle (SSLV) and Polar Satellite Launch Vehicle (PSLV) through technology transfer mechanisms.
 - Cater to emerging global commercial SSLV market demand by providing satellite building and satellite-based services, including supply of sub-systems for various domestic and international application needs.
 
Antrix
Antrix is the commercial arm of ISRO headquartered in Bangalore. It promotes and commercially markets the products and services emanating from the Indian Space Programme.
Complete article accessible only to IASNOVA PRO Subscribers.
Starlink network
American company SpaceX recently sent 60 small satellites (under 500 kg each) into Low Earth Orbit (LEO) for building low-cost Internet everywhere on Earth.
Space-based internet is the ability to use satellites in orbit around Earth to send and receive data. It provides better accessibility, more affordability, 24*7 availability and propels Internet of Things (IoT) technology.
GRAVITATIONAL LENSING
- NASA has announced that plan to use the phenomena of gravitational lensing in its research to know how new stars are born.
 - Use of James Webb Space Telescope
 - It is a natural phenomenon, which occurs when a huge amount of matter, such as a massive galaxy or cluster of galaxies, creates a gravitational field that distorts and magnifies the light from objects behind it, but in the same line of sight.
 
Quantum Computing
- Government in its Budget 2020 has announced the largest ever science mission- National Mission on Quantum Technologies & Applications (NMQTA).
 - Quantum computing is the area of study focused on developing computer technology based on the principles of quantum theory, which explains the nature and behaviour of energy and matter on the quantum (atomic and subatomic) level.
 
This is an important topic this year,we have covered it in detail in the Article on Emerging Technologies.
Quantum Supremacy- Sycamore
- Quantum supremacy means that researchers have been able to use a quantum computer to perform a single calculation that no conventional computer, even the biggest supercomputer, can perform in a reasonable amount of time.
 - Google’s quantum computer, named Sycamore, claimed ‘supremacy’ because it reportedly did the task in 200 seconds that would have apparently taken a supercomputer 10,000 years to complete.
 
Edge Computing
Edge computing enables data to be analysed, processed, and transferred at the edge of a network. Meaning, the data is analysed locally, closer to where it is stored, in real-time without latency.
- The basic difference between edge computing and cloud computing lies in where the data processing takes place.
 - In simple terms, cloud computing means storing and accessing data and programs over the Internet instead of your computer’s hard drive.
 - Currently, the existing Internet of Things (IoT) systems perform all of their computations in the cloud using data centres.
 - Edge computing, on the other hand, manages the massive amounts of data generated by IoT devices by storing and processing data locally.
 - Advantages- High speed, reduced latency & better reliability,better security,cost effective scalability.
 
Deep Web vs Surface Web
- Dark Web, Dark Net – that part of the Internet which cannot be accessed through traditional search engines like Google nor is it accessible by normal browsers like Chrome or Safari.
 - It generally uses non-standard communication protocols which makes it inaccessible to internet service providers (ISPs) or government authorities.
 - Encrypted content and use of specific browsers like TOR-The Onion Ring.
 - Part of Dark Web.
 
Dark Web
- Contains sites protected by passwords,doesnt throw results in search engines.
 - Dark web is generally accessible ,while Dark Net ,a part of Dark web is hidden.
 - Has positive uses also like -use by journalists in dictatorships to transfer information,students for research,medical records etc.
 
Surface Web
That part of internet which can be easily accessed and throws results on search engines.
Data Localization
- Data localization is a concept that the personal data of a country’s residents should be processed and stored in that country.
 - RBI announced that the payment system providers need to store entire payments data in a system only in India.
 - RBI issued a directive in April 2018 advising all Payment System Operators (PSOs) to ensure that the entire data relating to payment systems is stored within databases located in India within 6 months.
 - Directives are applicable to Payment System providers authorized by RBI under Payment and Settlement Systems Act, 2007.
 - There is no bar on overseas processing of strictly domestic transactions; but, the data should be deleted from the systems abroad and brought back to India not later than the one business day or 24 hours from payment processing, whichever is earlier.
 - RBI has rejected proposals by overseas service providers to allow data mirroring, which allows them to retain a copy of the data on their overseas servers as well.
 
3D Printing
- Israel created an world’s first 3D-printed heart made from human cells.
 - Read in detail in Article on Emerging Technologies- important topic.
 
Biometrics
- India has become the first country in the world to issue Biometric Seafarer Identity Document (BSID), capturing the facial bio-metric data of seafarers.
 - It has been developed with collaboration with Centre for Development of Advanced Computing (CDAC), Mumbai.
 - Read about Biometrics in Article on Emerging Technologies and Science and Tech.
 
Radio Frequency Identification (RFID)
Indian Railways (IR) is taking up Radio Frequency Identification (RFID) project which aims to automatically and accurately track and trace rolling stock as they move across the country with a special focus on improving their safety and reliability.
- RFID Tags by 2021
 - under Make in India initiative.
 
RFID Technology
- Sends data through radio waves.
 - Faster connection
 - Operational Range – 100 m
 - One way information only.
 
FASTag
- Under “One Nation One FASTag” scheme, the National Highway Authority of India (NHAI) is trying to get states on board so that one tag can be used seamlessly across highways.
 - Radio Frequency Identification (RFID) technology for payments.
 - Valid for 5 years and can be reacharged .
 - It is affixed on the windscreen that can enable electronic payment when it crosses a booth without stopping.
 
Space Weaponisation
US President has directed the establishment of the U.S. Space Force (USSF) as the sixth branch of the armed forces after the Army, Air Force, Navy, Marines, and Coast Guard which raises the debate on Weaponization of Space.
- Placing of weapons and weapons systems in outer space.
 - Weapons which can transit to outer spce from earth and attack targets in space.
 - Space- 4th frontier of war.
 
Different from Militarization of Space – which means placing space assets which assist in war on Earth -such as satellites which help in reconnaissance, surveillance, intelligence etc.
Outer Space Treaty
- adopted by UN GA in 1963,entered into force in 1967.
 - Treaty that forms the basis of international space law.
 - Provision wrt Space weaponisation– States shall not place nuclear weapons or other weapons of mass destruction in orbit or on celestial bodies or station them in outer space in any other manner.
 - No mention of other weapons in the treaty.
 - India is a signatory.
 
Avian Botulism
- Avian botulism became reason for bird deaths at Sambhar lake in Rajasthan.
 - Avian botulism is caused by a bacterium called Clostridium botulinum.
 - It affects the nervous system of birds, leading to flaccid paralysis in their legs and wings and neck touching the ground.
 - The bacteria is commonly found in the sail, river, and sea water.
 - Factors that favour the growth of bacetria include low levels of salinity, suitable temperature and high demand for chemical oxygen.
 
Anti-Microbial Resistance
- Interagency Coordination Group on Antimicrobial Resistance (IACG) has released a report titled, “No Time to Wait: Securing The Future From Drug Resistant Infections”, which highlights the financial fall-out of uncontrolled antimicrobial resistance.
 - Antimicrobial resistance (AMR) is the ability of a microorganism (like bacteria, viruses, and some parasites) to stop an antimicrobial (such as antibiotics, antivirals and anti-malarials) from working against it. As a result, standard treatments become ineffective, infections persist and may spread to others.
 
India
- The Drugs and Cosmetic Rule, 1945 were amended in 2013 to incorporate a new Schedule H1. These will be sold on prescription only. They are also marked with Red Line (Red Line Campaign).
 - Government has formulated a National Action Plan to combat Antimicrobial Resistance in 2017 and National Policy for containment of antimicrobial resistance in 2011.
 
AWaRe tool aims to guide antibiotic use globally
Using the “access,” “watch,” and “reserve” designations established previously, the World Health Organization (WHO) has created a new tool to limit the use of drugs associated with the highest risk of resistance and to increase the use of antibiotics in countries where supply and availability is low.
The tool, called AWaRe (for Access, Watch, and Reserve), was developed by the WHO Essential Medicines List to reduce the spread of antimicrobial resistance (AMR), antibiotic-related adverse events, and drug costs.
Colistin
Health ministry has banned the manufacture, sale and distribution of the antibiotic colistin and its formulations for food producing animals and animal feed supplements.
- The drug has been used for treating infections caused by Gram-negative bacilli, which are responsible for various diseases such as plague, cholera and typhoid.
 - It has side effects of nephrotoxicity and neurotoxicity.
 - Misuse of colistin in the poultry industry is said to be a major reason for the increase in antibiotic resistance in India.
 - According to the World Health Organisation (WHO), Colistin is a “reserve” antibiotic, which means it is supposed to be considered a “last resort” option.
 
Nano-Pharmaceuticals
Department of Biotechnology under Ministry of Science and Technology has prepared draft guidelines for evaluation of nano-pharmaceuticals in India.
Nanopharmaceuticals offer the ability to detect diseases at much earlier stages and the diagnostic applications could build upon conventional procedures using nanoparticles. Nanopharmaceuticals represent an emerging field where the sizes of the drug particle or a therapeutic delivery system work at the nanoscale.Such precision targeting via nanopharmaceuticals reduces toxic systemic side effects, resulting in better patient compliance.
A nanocarrier is a nanomaterial being used as a transport module for another substance like a drug.
Nanomaterials – size scale range of 1 to 100nm.
Food Fortification
Department of Food and Public Distribution under the Ministry of Consumer Affairs recently approved a centrally-sponsored pilot scheme on fortification of rice and its dispersal through Public Distribution System (PDS).
As per FSSAI, fortified foods are foods that help with the following:
- Foods that help prevent the risks of deficiency that are caused by the lack essential nutrients.
 - Foods that help reduce the inadequate nutritional level in the foods.
 - Foods that help in compensation with the required or recommended nutrients.
 - Foods that helps the body maintain and gain health.
 - Food that helps improve the nutritional quality of foods.
 
Trans-fat
The World Health Organization (WHO) has launched a comprehensive plan to eliminate industrially-produced artificial trans fats from the global food supply by 2023.
In tune with this commitment, the Draft Notifications of FSSAI, the Indian food safety regulator, state that the limit of trans fats in the fats/oils will be not more than 3% by weight on and from January 01, 2021 and not more than 2% by weight on and from January 01, 2022.
The current permitted level of trans fat is 5 percent (by weight) in India.
WHO calls on governments to use the REPLACE action package to eliminate industrially-produced trans-fatty acids from the food supply.
REPLACE- Review,Promote,Legislate,Assess,Create
Trans fats, or trans-fatty acids, are a form of unsaturated fat.
There are two main sources for trans fats:
- natural sources – in the dairy products and meat of ruminants such as cows and sheep.
 - artificial sources – They are created when
the oil goes through hydrogenation, which
involves adding hydrogen to the liquid oil to
make it more solid. 
They help to increase the shelf life of oils and foods and stabilise their flavours.
INTERNATIONAL INTELLECTUAL PROPERTY (IP) INDEX
International Intellectual Property Index 2020 was released by US Chamber of Commerce’s Global Innovation Policy Centre (GIPC).
India’s rank – 40/53
India’s Rank in 2019- 36/50
Top 5- US, the UK, Sweden, France and Germany.
Intellectual Property is an important topic for Prelims ,many questions have come in the previous years,should be done properly,one can check the article in our Pro Section.
Global Innovation Index
- India – 52/129 rank in 2019 ,57 in 2018
 - Developed by the World Intellectual Property Organization (WIPO) together with top business universities like Cornell University, INSEAD etc.
 
Bilateral Patent Prosecution Highway (PPH) Programme
On November 21, 2019, the Ministry of Commerce and Industry (Department for Promotion of Industry and Internal Trade, or DPIIT) issued a notification notifying the approved Bilateral Patent Prosecution Highway (PPH) Programme between the Indian Patent Office (IPO)and the Patent Offices of other interested countries/regions.
A Bilateral Patent Prosecution Highway (PPH) pilot program has commenced between the Indian Patent Office (IPO) and the Japan Patent Office (JPO) on December 5, 2019.Patent offices of India and Japan have inked an agreement for expeditious grant of patents to Indian entities and individuals by entering into the pilot programme on PPH for a period of three years.
Benefits of Patent Prosecution Highway:
- PPH will allow applicants to leverage allowance of claims from one office to another leading to an increase in domestic patent filings.
 - PPH will result in expeditious granting of patents in India
 - Expeditious examination through PPH shall result in high allowance rates and
 - significant cost savings would enable applicants to successfully and efficiently take advantage of their inventions in India.
 - PPH would encourage foreign applicants to enter the Indian market.
 
First Indigenous Fuel Cell system
- India’s first Indigenous Fuel Cell system
is developed by Council of Scientific and Industrial Research (CSIR) in partnership with Thermax Ltd, a Pune-based engineering firm. - Developed under the flagship program named ‘New Millennium Indian Technology Leadership Initiative (NMITLI).
 - Its a 5 kW fuel cell system and will use methanol/bio-methane to generate power with 70% more efficiency than other sources.
 
Fuel Cell Technology
- A fuel cell is a device that converts chemical potential energy (energy stored in molecular bonds) into electrical energy.
 - A PEM (Proton Exchange Membrane) cell uses hydrogen gas (H2) and oxygen gas (O2) as fuel.
 - The products of the reaction in the cell are water, electricity, and heat.
 
Hydrogen + Oxygen = Electricity + Water Vapor
Fuel cell,Batteries are important topics for Prelims and there are questions almost every year.We have covered these technologies in article on Emerging Technologies,Science and Tech-Part 4.One must also go through Electric Vehicles battery technology- important this year.
Microbial Fuel Cells
Microbial fuel cells (MFCs) are a new bioelectrochemical process that aims to produce electricity by using the electrons derived from biochemical reactions catalyzed by bacteria.
Microbial Fuel Cells (MFCs) have been described as “bioreactors that convert the energy in the chemical bonds of organic compounds into electrical energy through catalytic activity of micro-organisms under anaerobic conditions” . MFC technology represents a novel approach of using bacteria for generation of bioelectricity by oxidation of organic waste and renewable biomass .
The traditional MFC consisted of anode and cathode compartments but there are single chamber MFCs. Microorganisms actively catabolize substrate, and bioelectricities are generated. MFCs could be utilized as power generator in small devices such as biosensor.
- MFCs can use organic waste matter as fuels and readily available microbes as catalysts.
 - MFCs do not require highly regulated distribution systems like the ones needed for Hydrogen Fuel Cells.
 - MFCs have high conversion efficiency as compared to Enzymatic Fuel Cells, in harvesting up to 90% of the electrons from the bacterial electron transport system.
 - it could provide help with wastewater treatment and bioremediation.
 
HYDROTHERMAL CARBONISATION
- A research team at IIT Kharagpur has developed a technology which can generate energy from solid waste with high moisture content.
 - The new technology – Hydro Thermal Carbonization (HTC) – can convert wet municipal solid waste to biofuel, soil amendment and absorbents.
 - The moisture in the waste is used to the advantage of the process which uses water for the reaction. The biofuel generated as the recovered output can help curb air pollution.
 - The technology can be used by the civic bodies to effectively manage solid waste.
 - Once the organic waste is entered into the process, the outputs generated are all usable.
 - All outputs can be used for one purpose or the other, including the water which can be converted to biogas or methane.
 
Hydrothermal carbonization (HTC) is a thermochemical conversion technique which is attractive due to its ability to transform wet biomass into energy and chemicals without predrying. The solid product, known as hydrochar, has received attention because of its ability to prepare precursors of activated carbon in wastewater pollution remediation, soil remediation applications, solid fuels, and other carbonaceous materials. Besides the generally lignocellulose biomass used as sustainable feedstock, HTC has been applied to a wide range of derived waste, including sewage sludge, algae, and municipal solid waste to solve practical problems and generate desirable carbonaceous products.
Bio-Fuel
International Centre for Genetic Engineering and Biotechnology (ICGEB) scientists developed a method to improve the growth rate and sugar content of a marine microorganism – cyanobacterium called Synechococcus sp. PCC 7002 has been angineered for the purpose.
The two most common types of biofuels in use today are ethanol and biodiesel, both of which represent the first generation of biofuel technology.
Most ethanol is made from plant starches and sugars.
Cyanobacteria (blue-green algae) perform photosynthesis and produce sugar by fixing the carbon dioxide in the atmosphere- biofuel produced by algae is also called algal biofuel.
Read about Biofuels in our article on Unconventional Sources of Energy- important for Prelims exam.
India adopts new definition of kilogram
India adopted a global resolution to redefine four of the seven base units — kilogramme, kelvin, mole and ampere.
- A resolution to redefine four of the seven base units was passed by representatives of 60 countries at the General Conference on Weights and Measures (CGPM) of the International Bureau of Weights and Measures (BIPM), Paris.
 - Over 100 countries have adopted the metric system of measurements, also known as the International System of Units (SI), which has been in practice since 1889.
 - The other base units are — second, metre and candela.
 - Earlier, the kilogram derived its provenance from the weight of a block of a platinum iridium alloyhoused at the International Bureau of Weights and Measures in Paris.
 - The new SI System will be helpful in bringing in accuracy while dealing with international trade, biotechnology, high-tech manufacturing and human health and safety.
 - The new definition of kg involves accurate weighing machines called ‘Kibble balance’, which uses Planck’s Constant to measure the mass of an object using a precisely measured electromagnetic force.
 
Superconductivity at Room Temperature
A team from the Indian Institute of Science (IISc), Bengaluru has come up with a material, which exhibits major properties of superconductivity at ambient temperature and pressure.
Superconductivity, complete disappearance of electrical resistance in various solids when they are cooled below a characteristic temperature. This temperature, called thetransition temperature, varies for different materials but generally is below 20 K (−253 °C).
- Applications– medical magnetic-imaging devices, magnetic energy-storage systems, motors, generators, transformers, computer parts, and very sensitive devices for measuring magnetic fields, voltages, or currents.
 
Advantages
- low power dissipation,
 - high-speed operation,
 - high sensitivity.
 
Applications of Room/Higher Temperature Superconductors
- Construction of computer parts (logic devices, memory elements, switches, and interconnects), oscillators, amplifiers, particle accelerators, highly sensitive devices for measuring magnetic fields, voltages or currents, magnets for medical magnetic-imaging devices, magnetic energy-storage systems, levitated passenger trains for high-speed travel, motors, generators, transformers, and transmission lines.
 
Advantages of Room temp/ High temp. Superconductors
- Low power dissipation,
 - high operating speed,
 - extreme sensitivity,
 - more economical to operate.
 
Superconductor material classes include –
- chemical elements (e.g. mercury or lead),
 - alloys (such as niobium –titanium, germanium–niobium, and niobium nitride),
 - ceramics (YBCO and magnesium diboride),
 - superconducting pnictides (like fluorine-doped LaOFeAs) or
 - organic superconductors (fullerenes and carbon nanotubes).
 
2 famous applications of Superconductors :
- SQUIDs (Superconducting Quantum Interference Devices) are used to detect even the weakest magnetic field. They are used in mine detection equipment to help in the removal of land mines.
 - Large hadron collider or particle accelerator – Superconductors are used to make extremely powerful electromagnets to accelerate charged particles very fast (to near the speed of light).
 
Proton Therapy
Vice President of India inaugurated India’s first proton therapy centre in Chennai for the treatment of Cancer- Apollo Proton Cancer Centre- South Asia’s first such centre.
Proton therapy is a type of radiation therapy — a treatment that uses high-energy beams to treat tumors. Radiation therapy using X-rays has long been used to treat cancers and noncancerous (benign) tumors.
Proton therapy is a newer type of radiation therapy that uses energy from positively charged particles called protons.
Proton therapy is used as a treatment for cancer and some noncancerous tumors.
Advantages
- Precision in treatment
 - Less side effects
 
Disadvantages
- Specialised and expensive
 - Not applicable to all types of cancers
 - More research and clinical trials needed.
 
Optoelectronics
Researchers from IIT Madras have found a way of enhancing the optoelectronic properties of tungsten diselenide.
- Optoelectronics is the communication between optics and electronics which includes the study, design and manufacture of a hardware device that converts electrical energy into light and light into energy through semiconductors. This device is made from solid crystalline materials which are lighter than metals and heavier than insulators. Optoelectronics device is basically an electronic device involving light. This device can be found in many optoelectronics applications like military services, telecommunications, automatic access control systems and medical equipments.
 - In short- its study and application of electronic devices and systems that source, detect and control light.
 - In this context, light often includes invisible forms of radiation such as gamma rays, X-rays, ultraviolet and infrared, in addition to visible light.
 Examples of optoelectronic devices include telecommunication laser, blue laser, optical fiber, LED traffic lights, photo diodes and solar cells.
Majority of the optoelectronic devices (direct conversion between electrons and photons) are LEDs, laser diodes, photo diodes and solar cells.
Short Wave Radio Transmission
Prasar Bharati has asked All India Radio (AIR) to come up with a proposal to phase out Short Wave (SW) transmitters.
- Shortwave radio is radio transmission using shortwave radio frequencies, the range always includes all of the high frequency band (HF), and generally extends from 3-30 MHz (10 to 100 meters), above the medium frequency band (MF), to the end of the HF band.
 - Radio waves in the shortwave band can be reflected or refracted from a layer of electrically charged atoms in the atmosphere called the ionosphere.
 - Therefore, short waves directed at an angle into the sky can be reflected back to Earth at great distances, beyond the horizon.
 - This is called skywave or “skip” propagation, thus shortwave radio can be used for very long distance communication, in contrast to radio waves of higher frequency which travel in straight lines (line-of-sight propagation) and are limited by the visual horizon, about 64 km (40 miles).
 - Shortwave radio is used for broadcasting of voice and music to shortwave listeners over very large areas, sometimes entire continents or beyond.
 - It is also used for military over-the-horizon radar, diplomatic communication, and two-way international communication by amateur radio enthusiasts.
 
Ceramic Membranes
Central Glass and Ceramic Research Institute, Kolkata has developed Ceramic Membranes for treatment of water contaminated with heavy metals.
Ceramic membranes are a type of artificial membranes made from inorganic materials (such as alumina, titania, zirconia oxides, silicon carbide or some glassy materials). They are used in membrane operations for liquid filtration.
By contrast with polymeric membranes, they can be used in separations where aggressive media (acids, strong solvents) are present. They also have excellent thermal stability which makes them usable in high-temperature membrane operations.
Advantages :
- Absorption capacity is upto 8 times higher than other membranes
 - Minimises water wastage and can operate under harsh operating environments.
 - These membranes last for around 10-15 years without replacement.
 - They can also be used in other sectors like food and beverage, drug and chemicals, waste recovery and recycling industries and are especially useful in petrochemical processing, where it is not possible to use organic membranes.
 
Elastocaloric Effect
According to a research published in the Journal Science, the elastocaloric effect, if harnessed, may be able to do away with the need of fluid refrigerants used in fridges and air-conditioners.
- The elastocaloric effect occurs when a material undergoes a transition in its crystal structure when it is squeezed.
 - Advantages-greener, higher-efficiency and low-cost cooling technology.
 
SCIENTIFIC SOCIAL RESPONSIBILITY (SSR)
Department of Science and Technology (DST) released a draft of its proposed Scientific Social Responsibility (SSR) policy.
UPDATE
Earth BioGenome project
- It is a global effort launched in 2018, involving scientific partners and funders from around the globe with an aim to  sequence, catalogue and characterise genomes of all of Earth’s eukaryotic biodiversity over a period of ten
years. 
Indian Initiative on Earth BioGenome Sequencing (IIEBS)
- Aims to decode the genetic information of all known species of plants and animals in the country.
 - The National Institute of Plant Genome Research, New Delhi is the coordinating centre.
 - Part of the Earth BioGenome Project.
 
Genome Sequencing is an important topics nowadays,in fact any new topic in Biotechnology should be done properly.
GW190412
- GW190412 is first observation of a Binary Black Hole (BBH) Merger where two black holes of distinctly different masses merged.
 
Sun Spots
- Sunspots are areas that appear dark on the surface of the Sun and are cooler than other parts of the Sun’s surface.
 - They form at areas where magnetic fields are so strong that they keep some of the heat within the Sun from reaching the surface.
 - It may be correlated with climate on earth.
 
Kepler-1649c
- It is Earth-size exoplanet 300 light-years away which was recently discovered from data of NASA’s Kepler space telescope.
 - It revolves around its star in the habitable zone— the area around a star where a rocky planet could support liquid water.
 - It is only 1.06 times larger than Earth.
 
Cryptocurrency
- Cryptocurrency is a type of digital currency that uses cryptography for security and anticounterfeiting measures.
 - It is normally not issued by any central authority, making it immune to government interference or manipulation.
 - The control of each cryptocurrency works through distributed ledger technology called blockchain.
 - Examples include Bitcoin, Ethereum, Ripple
etc 
Cryptocurrency is an important topic this year,go through the article in Pro Section on Cryptocurrency and Blockchain Technology.
National Supercomputing Mission
- NSM was launched in 2015 to empower national academic and R&D institutions by installing a vast supercomputing grid comprising of more than 70 high-performance computing facilities.
 - NSM is jointly implemented by Ministry of Electronics and IT and Department of Science and Technology along with C-DAC and IISc as executing agencies.
 - Under NSM, Param Shivay – first supercomputer was assembled indigenously is installed in IIT (BHU).
 
Top-500 Project
- Started in 1993, it ranks the 500 most powerful non-distributed computers in the world.
 - Currently, China dominates the list with 229 supercomputers, leading the second place (United States) by a record margin of 121.
 - Japan’s Fugaku supercomputer is the world’s most powerful supercomputer, based on the LINPACK benchmarks.
 - LINPACK benchmark are a measure of a system’s floating point computer power. It measures how far a computer solves a system of linear equations.
 - India has 4 supercomputers in the Top-500 list of the world’s top 500 supercomputers with Pratyush and Mihir being the fastest supercomputers in India.
 
MAC-Binding
- Mac-binding means binding together the MAC and IP addresses, so that all requests from that IP address are served only by the computer having that particular MAC address.
 - It was applied in Jammu and Kashmir while restoring net connectivity.
 
Maze Ransomware
- IT services provider Cognizant had faced Maze ransomware attack.
 - A ransomware attack infects computers in a network and encrypts files on these computers and then demands a ransom to recover the files.
 - In 2019, Global cybersecurity firm Kaspersky Security identified three prominent ransomwares- Ryuk, Purga and Stop.
 - India was attacked by all three groups of ransomwares.
 
Nanotechnology in Agriculture
- Centre has released ‘Guidelines for Evaluation of Nano-based Agri-input and food products’ in India.
 - The unique physicochemical properties of nanomaterials, that is, catalytic reactivity, high surface area, size and shape, have the potential to open new paradigms and to introduce new strategies in agriculture.
 - These regulations will oversee the use and spread of hundreds of nano-agri input products (NAIP) and nano-agriproducts (NAP) which have been circulating in the Indian market for some years now, to prevent nanoparticle toxicity in humans and the environment.
 - NAIPs and NAPs are products in a submicroscopic form used in agriculture and allied sectors for achieving varied goals like pest and disease prevention, nutrition, growth regulation, efficient packaging and storage among others.
 - Nano-biotechnology has been an important area for the government of India which had launched a National Nano Mission in 2007 that looks at the uses of nanotechnology for safe drinking water, materials development, sensors development, drug delivery, etc.
 - Department of Science and Technology (DST) is the nodal agency for implementing the nano mission.
 - Department of Biotechnology’s (DBT) role is to promote its applications in various sectors of life sciences.
 
Uses of Nanotechnology in Agriculture
- Nano-fertilisers can significantly increase the nutrient use efficiency and provide stress tolerating ability to crops as well as reduce environmental pollution by reducing fertiliser nutrient run-off into ground and surface water.
 - Use of nanotechnology in agriculture aims to reduce nutrient losses and the amount of agrochemicals used, by ensuring the smart delivery of active compounds and increased productivity through optimised water and nutrient management.
 - Higher crop yield and better crop protection
 
NAIPs include products, like nano fertilisers and nanopesticides, that are intended to be used in agriculture and allied sectors for crop production, protection, management, harvesting, post-harvesting and packaging.
NAPs, like nano-food and nano-feeds, cover “agriproducts in the nano form of finished food formulation, finished feed formulations, nano processing aids, nanocomposites for food packaging and nano-sensors for food packaging and food safety applications.”
Gold Nanoparticles
- National Centre for Polar and Ocean Research and the Goa University has successfully synthesized GNPs using psychrotolerant Antarctic bacteria.
 - GNP’s biocompatibility, high surface area, stability, and nontoxicity make them suitable for various applications in therapeutic use including detection and diagnosis of diseases, bio-labelling, and targeted drug delivery.
 - GNPs are also found to be useful in the electronics industry.
 
Joint Lunar Polar Exploration Mission
- It was conceptualized as joint mission between JAXA and ISRO in 2017 which aims to put a lander and a rover on the Moon’s surface.
 - As per details shared by JAXA , it will be launched after 2023.
 - The mission would last for about six months and will target a constantly sunlit region near the Moon’s South Pole.
 - JAXA would be building the overall landing module and rover and ISRO would develop lander system.
 
LiDAR
- LiDAR is a remote sensing technology that uses light in the form of a pulsed laser to measure ranges (distances) to a target.
 - These light pulses—combined with other data recorded by the airborne system— generate precise, three- dimensional information about the shape of the Earth and its surface characteristics.
 - It is similar to radar and sonar (that use radio and sound waves)
 - Lidar systems allow scientists and mapping professionals to examine both natural and manmade environments with accuracy, precision, and flexibility.
 - Applications- Land management and planning efforts, including hazard assessment, forestry, agriculture, geologic mapping, and watershed and river surveys etc.
 
MARS MISSIONS
Mangalayan- India
MARS 2020- NASA,US
Tianwen 1 or Quest for Heavenly Truth 1- China
Recently, Mangalayan sent images of Mars’ biggest and closest moon Phobos and its craters.Mars has two moons, the other being Deimos.
Global magnetic field of Sun’s atmosphere measured for the first time
- Global magnetic field of the Sun’s corona, or outer atmosphere, measured for the very first time.
 - The team used a technique known as coronal seismology or magnetoseismology to measure the coronal magnetic field which has been known for a few decades. This method requires the measurement of the properties of magnetohydrodynamic (MHD) waves and the density of the corona simultaneously.
 - The waves that propagate through a magnetic plasma are called magnetohydrodynamic (MHD) waves.
 - India’s first solar mission, Aditya-L1 satellite will aim to measure the solar coronal magnetic fields regularly.
 
Study will help in understanding
- Reasons which causes corona to heat up, though the photosphere is cooler than the interior.
 - Mechanisms of eruptions of the Sun, such as solar flares and coronal mass ejections.
 
Indian National Space Promotion and Authorization Centre (INSPACe)
- Government of India has created INSPACe to boost private sector participation in entire range of space activities.
 - It is the new entity of the Department of Space which will have its own chairperson and board.
 - It will regulate and promote building of routine satellites, rockets and commercial launch services through Indian industry and startups.
 - It will have its own directorates for technical, legal, safety and security, monitoring and activities promotion.
 - It will act as an interface between ISRO and private parties.
 - It will function autonomously and parallel to ISRO.
 - Indian Space Research Organisation (ISRO) will remain the basic body that decides what missions are to be undertaken but IN-SPACe will help fill the gaps.
 - It is the second space organisation created by the government in the last two years. The first one was New Space India Limited (NSIL) after it was announced in 2019 Budget.
 
Global Partnership on Artificial Intelligence- GPAI
- India joined GPAI as a founding member.
 - GPAI is multi-stakeholder international partnership to promote responsible and human centric development and use of AI, grounded in human rights, inclusion, diversity, innovation, and economic growth.
 - GPAI will be supported by a Secretariat, to be hosted by Organization for Economic Cooperation and Development (OECD) in Paris.
 
India Tuberculosis Report 2020
- Due to easy availability of molecular diagnostics, proportion of children diagnosed with TB increased to 8% in 2019 compared to 6% in 2018.
 - Improvement in treatment success rate is 81% in 2019 (69% in 2018).
 - State Rankings-
 - Gujarat, Andhra Pradesh and Himachal Pradesh performed best among large states.
 - Tripura and Nagaland performed best among small states.
 - Dadara and Nagar Haveli, and Daman & Diu- among UTs
 
G6PD deficiency
- G6PD deficiency is a genetic abnormality that results in an inadequate amount of glucose-6- phosphate dehydrogenase (G6PD) in the blood.
 - This is a very important enzyme (or protein) that regulates various biochemical reactions in the body.
 - G6PD is also responsible for keeping red blood cells healthy .
 - Surat Municipal Corporation (SMC) has raised a specific COVID-19 alert for Vataliya Prajapati community whose 25% population suffers from a genetic blood disorder called G6PD deficiency.
 
UN Report on Zoonotic Diseases
- Released by United Nations Environment Programme and International Livestock Research Institute highlighting increasing trend of Zoonotic diseases.
 - “Zoonotic disease (ZD)” or “zoonosis” is a disease that has passed into the human population from an animal source. It can be bacterial, viral, or parasitic in nature such as Ebola, malaria, rabies, COVID-19 etc.
 
Report Findings
- About 60% of human infections are estimated to have an animal origin. Further 75% of emerging infectious diseases are zoonotic.
 - Report identifies One Health approach, which unites public health, veterinary and environmental expertise, as the optimal method for preventing as well as responding to zoonotic disease outbreaks and pandemics.
 
Patent Pooling
- According to World Intellectual Property Organisation (WIPO), patent pools are defined as an agreement made between two or more patent holders for licensing their patents to one another or any third party for the purpose of sharing their intellectual property rights.
 - Generally, patents pools are made for complex technologies which necessitate complementary patents for providing productive technical solutions such as vaccines in the present Covid-19 crisis.
 - Sewing Machine Combination of 1856 is considered as the first modern patent pool in the United States.
 - It ensures innovation between companies,lower transaction costs and better process efficiencies.
 
‘Accelerate Vigyan’ scheme
- launched by Science and Engineering Research Board (SERB)
 - The scheme is to boost high-end scientific research and prepare scientific manpower that can venture into research careers by identifying research potential, mentoring, training and giving hands-on workshops on a national scale.
 
5th State of Matter
- NASA Scientists observed the fifth state of matter in space for the first time as part of Bose Einstein Condensates (BEC) Experiments aboard the International Space Station (ISS).
 - The existence of Bose Einstein Condensate, also known as the fifth state of matter was predicted by Albert Einstein and Indian mathematician Satyendra Nath Bose .
 - Solids, liquids, gases and plasma are the other four states of matter.
 - BEC is a supercooled gas that no longer behaves as individual atoms and particles, but rather an entity in a single quantum state.
 - BECs are formed when atoms of certain elements are cooled to near absolute zero (0 Kelvin, minus 273.15 Celsius).
 
